Adhesion-GPCRs: structure to function

by Stacey, Martin Yona, Simon

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Title Statements

Full title :Adhesion-GPCRs : structure to function / edited by Simon Yona, Martin Stacey.

Summary

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Edition Statements

Publication Date:©2010.

Publication Statements

Publisher(s):Landes Bioscience, Springer Science+Business Media
Place of Publication:New York
Language:eng
Publication Date:©2010.

The Physical Object

Description:1 online resource (xxi, 199 pages) : : illustrations

Edition Identifiers

ISBN:9781441979131, 1441979131, 9781441979124, 1441979123
oclc:ocn745001322
LC Classification:QP552.G16
Dewey Decimal:572/.69

The adhesion GPCRs : gene repertoire, phylogeny, and evolution / Helgi B. Schith, Karl J.V. Nordstrom, and Robert Fredriksson -- Cadherins : developmental roles and future challenges / Caroline J. Formstone -- Latrophilin signalling in tissue polarity and morphogenesis / Tobias Langenhan and Andreas P. Russ -- GPS proteolytic cleavage of adhesion-GPCRs / Hsi-Hsien Lin [and others] -- The latrophilins : "split-personality" receptors / John-Paul Silva and Yuri A. Ushkaryov -- Studies on the very large G protein-coupled-receptor : from initial discovery to determining its role in sensorineural deafness in higher animals / D. Randy McMillan and Perrin C. White -- Adhesion-GPCRs in the CNS / Natalie Strokes and Xianhua Piao -- GPR56 interacts with extracellular matrix and regulates cancer progression / Lei Xu -- Adhesion-GPCRs in tumorigenesis / Gabriela Aust -- Immunity and adhesion-GPCRs / Simon Yona, Hsi-Hsien Lin, and Martin Stacey -- CD97 in leukocyte trafficking / Jorg Hamann [and others] -- The role of CD97 in regulating adaptive T-cell responses / Ian Spendlove and Ruhcha Sutavani -- F4/80 : the macrophage specific adhesion-GPCR and its role in immunoregulation / Hsi-Hsien Lin …

Subjects

Antigens, CD -- physiology Biomedicine biomedische wetenschappen Cell Adhesion Molecules Cell receptors G proteins geneeskunde Geneeskunde (algemeen) GTP-Binding Proteins Medicine Medicine (General) Molécules d'adhésion cellulaire Proteïnes G. Récepteurs cellulaires Receptors, Cell Surface Receptors, G-Protein-Coupled -- genetics