Advances in cancer research

by Tew, Kenneth D.

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Title Statements

Full title :Advances in cancer research.

Edition Statements

Publication Date:©2016
Edition:First edition

Publication Statements

Publisher(s):Academic Press
Place of Publication:Amsterdam, [Netherlands]
Language:eng
Publication Date:©2016

Notes

Description based upon print version of record.

3.1.2. Staphylococcal Nuclease Domain-Containing Protein 1

The Physical Object

Description:1 online resource (224 p.).

Edition Identifiers

ISBN:0128051809, 9780128051801, 0128047887, 9780128047880
oclc:on1159612010
LC Classification:RC267
Dewey Decimal:616.9940072

Front Cover; Advances in Cancer Research; Copyright; Contents; Contributors; Chapter One: The Dual Role of Senescence in Pancreatic Ductal Adenocarcinoma; 1. Introduction; 1.1. Pancreatic Ductal Adenocarcinoma: An Overview; 1.2. The Biological Relevance of Cellular Senescence; 2. Senescent Cells in Pancreatic Cancer; 2.1. Senescence in Pancreatic Tumor Cells; 2.2. Senescence as Barrier to PDAC Progression; 2.3. Senescence Bypass in PDAC; 2.4. Epigenetic Regulation of the Senescent State in PDAC; 2.5. Senescence in Pancreatic Stellate Cells; 3. Senescence and Inflammation in Pancreatic Cancer

3.1. The SASP Links Senescence to Inflammation3.2. Senescence-Inflammation Interface in PDAC; 4. Conclusions and Some Unanswered Questions; 4.1. Oncogenic Kras as Primary Inducer of Senescence in PDAC; 4.2. Bidirectional Reversibility of the Senescent State; 4.3. On the Pro- and Antitumorigenic Roles of Senescence; 4.4. Senescent Cell-Immune Cell Interactions; Acknowledgments; References; Chapter Two: Small-Molecule Targeting of BET Proteins in Cancer; 1. Introduction; 2. BET Proteins; 2.1. The Bromodomain; 2.2. BET Function; 2.3. BETs in Health and Disease; 3. BET Inhibitors; 3.1. Discovery
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