Advances in clinical chemistry

Advances in Clinical Chemistry, Volume 75, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. This serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Front Cover; Advances in Clinical Chemistry; Copyright; Contents; Contributors; Preface; Chapter One: Capillary Electrophoresis-Mass Spectrometry for Clinical Metabolomics; 1. Introduction; 2. CE-MS Methodology; 2.1. CE Modes and Separation Conditions; 2.2. Interfacing Aspects of CE-MS; 3. Clinical Metabolomics; 3.1. General Aspects; 3.2. Strategies for Data Analysis; 3.3. Applications; 4. Conclusions and Perspectives; Acknowledgments; References; Chapter Two: Metabolomics in Newborns; 1. Introduction; 2. Data Analysis in Metabolomics; 3. Metabolomics in Neonatology; 3.1. Prematurity

3.2. Intrauterine Growth Retardation3.3. Inborn Errors of Metabolism; 3.4. Perinatal Asphyxia; 3.5. Sepsis; 3.6. Necrotizing Enterocolitis; 3.7. Kidney Disease; 3.8. Bronchopulmonary Dysplasia; 3.9. Cardiac Malformation and Dysfunction; 4. Conclusions; References; Chapter Three: Maternal Plasma DNA and RNA Sequencing for Prenatal Testing; 1. Introduction; 2. History; 2.1. Why Prenatal Screening for Aneuploidy?; 2.2. History of Invasive Prenatal Screening; 2.3. History of Noninvasive Prenatal Screening; 2.4. History of NIPT; 3. Background of NIPT

4. Different Techniques and Bioinformatic Approaches4.…