Antibody therapeutics

by Adair, John R. Harris, William J.

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Title Statements

Full title :Antibody therapeutics / edited by William J. Harris, John R. Adair.

Summary

Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.

Edition Statements

Publication Date:1997.

Publication Statements

Publisher(s):CRC Press
Place of Publication:Boca Raton, Fla
Language:eng
Publication Date:1997.

The Physical Object

Description:1 online resource (366 pages) : : illustrations

Edition Identifiers

ISBN:9780429260360, 0429260369, 9780429535987, 0429535988, 9780429550683, 0429550685, 9780429522512, 0429522517
DOI:10.1201/9780429260360
oclc:on1123193699
LC Classification:RM282.I44
Dewey Decimal:615/.37

pt. 1. Antibodies as therapeutics. Unconjugated antibodies as therapeutics / M. Clark -- Immunotoxins for treating cancer and autoimmune disease / R.J. Kreitman and I. Pastan -- Antibodies as carriers for drugs and radioisotopes / G. Yarranton -- Tumor targeting by antibody-drug conjugates / I. Benhar and I. Pastan -- pt. 2. Application of antibody therapeutics. Therapeutic antibodies in infectious disease / W.J. Harris -- Antibody therapeutics: application to autoimmunity / L. Chatenoud -- Monoclonal antibodies in transplantation / M.-L. Alegre -- pt. 3. Development of antibody therapeutics. Regulatory issues for the development of antibody therapeutics / K.J. Lambert -- Manufacture of antibodies by large-scale mammalian cell culture / D.K. Robinson, V. Yabannavar and Y. Deo -- Production of antibody domains in prokaryotes / M. Better and P. Gavit -- Emerging production systems for antibody therapeutics / A.J.R. Porter, K.J. Bentley, P.M. Cupit and T.P. Wallace -- pt. 4. Recombinant antibodies in the clinic. Development of Zenapax: a humanized anti-tac antibody / J. Hakimi ... et al. -- Progress with a reshaped human monoclonal antibody, RSHZ19, for the prophylaxis and treatment …

Subjects

Antibodies, Monoclonal -- therapeutic u… Anticorps monoclonaux -- Emploi en thér… Antikörper Aufsatzsammlung Immunoglobulins -- Therapeutic use Immuntherapie MEDICAL -- Immunology MEDICAL -- Pharmacology MEDICAL -- Toxicology Monoclonal antibodies -- Therapeutic use Monoklonaler Antikörper