Anticandidal Agents

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics.

Front Cover; Anticandidal Agents; Copyright Page; Contents; List of Figures; List of Tables; 1 Introduction; Pathogenesis and Virulence; Genome and Proteome; Genetics; Metabolome; 2 Host-Pathogen Interaction; Morphogenesis; Immune Responses; Delayed-Type Hypersensitivity; Pattern Recognition Receptors; TH Cell Response; 3 Antifungals Used Against Candidiasis; Azoles; Activity and Mechanism of Action; Azole Variants and Their Structure; Ketoconazole; Itraconazole; Fluconazole; Voriconazole; Posoconazole; Ravuconazole; Terconazole; Other Notable Triazoles Include; Polyenes.

Activity and Mechanism of ActionStructure and Variants; Amphotericin B; Nystatin; Natamycin; Echinocandins; Activity and Mechanism of Action; Echinocandins Variants; Caspofungin; Micafungin; Anidulafungin; Pneumocandins; Echinocandin B; Cilofungin; Allylamines; Activity and Mechanism of Action; Variants of Allylamines; Terbinafine; Naftifine; Pyrimidines; Activity and Mechanism of Action; Pyrimidine Variants; 5-FC or Flucytosine; Thiocarbamates and Morpholines; Tolnaftate; Morpholines; Other Inhibitors; Cell Wall Synthesis Inhibitors; Chitin Biosynthesis Inhibitors.

Ergosterol Biosynthesis InhibitorGlucan Synth…