Antimalarial natural products
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, includ…
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- Full title :Antimalarial natural products / A. Douglas Kinghorn, Heinz Falk, Simon Gibbons [et al.], editors ; by David G. I. Kingston and Maria Belen Cassera.
Summary
This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
Read More ↓Edition Statements
- Publication Date:copyright 2022
Publication Statements
- Publisher(s):Springer
- Place of Publication:Cham, Switzerland
- Language:eng
- Publication Date:copyright 2022
Notes
Autres contributeurs : Yoshinori Asakawa, Ji-Kai Liu, Verena M. Dirsch.
The Physical Object
- Description:1 vol. (ix-106 p.) : : ill., couv. ill. en coul. ; : 25 cm.
Edition Identifiers
- ISBN:3030898725 (rel), 9783030898724 (rel), 9783030898755 (br), 303089875X (br), 3030898733, 9783030898731
- oclc:on1309071697
- Dewey Decimal:616.9362061
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