Bacterial type III protein secretion systems

by Galan, Jorge E. Wagner, Samuel

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Title Statements

Full title :Bacterial type III protein secretion systems / Samuel Wagner, Jorge E. Galan, editors.

Summary

One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogens benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.

Edition Statements

Publication Date:2020.

Publication Statements

Publisher(s):Springer
Place of Publication:Cham, Switzerland
Language:eng
Publication Date:2020.

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9783030521233, 3030521230
DOI:10.1007/978-3-030-52123-3
oclc:on1184680829
LC Classification:QR46
Dewey Decimal:579.3/165

Intro -- Preface -- Contents -- 210 A Unified Nomenclature for Injectisome-Type Type III Secretion Systems -- Abstract -- References -- 168 Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion -- Abstract -- 1 Introduction -- 2 T3SS Regulation on the Transcriptional Level -- 2.1 Control by Central Transcriptional Activators -- 2.2 Transcriptional Control of the Key T3SS Regulators -- 2.3 Silencing and Activation of T3SS Master Regulator Expression by Modulator Proteins -- 3 T3SS Regulation on the Post-transcriptional Level -- 3.1 Control of Translation

3.1.1 Sensory RNAs-RNA Thermometers -- 3.1.2 Translational Control by CsrA/RsmA RNA-Binding Proteins -- 3.2 Control of T3SS mRNA Structures and Stability-Influence of Helicases and RNases -- 3.3 Regulatory RNAs -- 3.4 Feedback Control Mechanisms Through Secreted Effectors or Anti-sigma Factors -- 4 T3SS Regulation on the Protein Level -- 4.1 Changing Binding Partners -- 4.2 Modulation or Modification of T3SS Regulatory Components -- 5 Conclusions and Future Perspectives -- References -- 164 Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System -- Abstract

1 Intro…

Subjects

Bacteria -- Physiology Bacterial Physiological Phenomena Bactéries -- Physiologie Bactéries pathogènes Bacteriology (non-medical) Infectious & contagious diseases MEDICAL -- Infectious Diseases Medical Microbiology Medical microbiology & virology Pathogenic bacteria SCIENCE -- Life Sciences