Bioconjugate techniques

Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.<b.

Description based upon print version of record.

Oxidase Modification of Sugar Residues

Front Cover; Bioconjugate Techniques; Copyright Page; Detailed Contents; Preface to the Second Edition; Preface to the First Edition; Acknowledgments; Health and Safety; Intellectual Property; PART I: Bioconjugate Chemistry; Chapter 1. Functional Targets; 1. Modification of Amino acids, Peptides, and Proteins; 1.1. Protein Structure and Reactivity; Amino Acids; Nucleophilic Reactions and the pI of Amino Acid Side Chains; Secondary, Tertiary, and Quaternary Structure; Prosthetic Groups, Cofactors, and Post-Translational Modifications; Protecting the Native Conformation and Activity of Proteins

Oxidation of Amino Acids in Proteins and PeptidesSolvent Accessibility of Functional Targets in Proteins; 1.2. Protein Crosslinking Methods; 2. Modification of Sugars, Polysaccharides, and Glycoconjugates; 2.1. Carbohydrate Structure and Functionality; Basic Sugar Structure; Sugar Functional Groups; Polysaccharide and Glycoconjugate Structure; 2.2. Carbohydrate and Glycan Conjugation Methods; 3. Modification of Nucleic Acids and Oligonucleotides; 3.1. Polynucleotide Structure and Functionality; Nucleotide Functional Groups; RNA and DNA Structure; 3.2. Polynucleotide Crosslinking Methods

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