Bioconjugation

Bioconjugation: methods and protocols

by Devoogdt, Nick Massa, Sam

Type Book
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This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or the…

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Title Statements

  • Full title :Bioconjugation : methods and protocols / edited by Sam Massa, Nick Devoogdt.

Summary

This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins. Although centered on the development of bioconjugates rather than their application, most protocols also show the conjugation of the targeting vehicle to a diagnostic or therapeutic entity, with the end-product most often being an antibody-drug conjugate, an optical probe, a nanomedicine, or a radiopharmaceutical. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Bioconjugation: Methods and Protocols is an ideal guide for researchers looking toward precision medicine in order to expand the vital field of drug discovery.

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Edition Statements

  • Publication Date:2019

Publication Statements

  • Publisher(s):Humana Press
  • Place of Publication:New York, NY
  • Language:eng
  • Publication Date:2019

The Physical Object

  • Description:xi, 317 pages : : illustrations (some color) ; : 27 cm.

Edition Identifiers

  • ISBN:9781493996537, 1493996533
  • oclc:on1097674153
  • LC Classification:QR186.85
  • Dewey Decimal:616.0798

Subjects

Antibodies, Monoclonal Antibodies, Monoclonal -- chemistry Anticorps monoclonaux biochemistry Biochimie Chemistry, Pharmaceutical Chimie pharmaceutique Immunoconjugates -- chemistry Laboratory Manual Laboratory manuals Manuels de laboratoire Monoclonal antibodies Pharmaceutical chemistry Precision Medicine -- methods Proteins -- chemistry Toxicologie Toxicology

Writers

Devoogdt, Nick Massa, Sam

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