Bioinformatics for biologists

The computational education of biologists is changing to prepare students for facing the complex data sets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking.

Part I. Genomes: 1. Identifying the genetic basis of disease / Vineet Bafna; 2. Pattern identification in a haplotype block / Kun-Mao Chao; 3. Genome reconstruction: a puzzle with a billion pieces / Phillip Compeau and Pavel Pevzner; 4. Dynamic programming: one algorithmic key for many biological locks / Mikhail Gelfand; 5. Measuring evidence: who's your daddy? / Christopher Lee; Part II. Gene Transcription and Regulation: 6. How do replication and transcription change genomes? / Andrei Grigoriev; 7. Modeling regulatory motifs / Sridhar Hannenhalli; 8. How does influenza virus jump from animals to humans? / Haixu Tang; Part III. Evolution: 9. Genome rearrangements / Steffen Heber and Brian Howard; 10. The crisis of the tree of life concept and the search for order in the phylogenetic forest / Eugene Koonin, Pere Puigb- and Yuri Wolf; 11. Reconstructing the history of large-scale genomic changes: biological questions and computational challenges / Jian Ma; Part IV. Phylogeny: 12. Figs, wasps, gophers, and lice: a computational exploration of coevolution / Ran Libeskind-Hadas; 13. Big cat phylogenies, consensus trees, and computational thinking / Seung-Jil Sun and Tiffani Williams; …