Biologic foundations for skeletal tissue engineering

by Bueno, Ericka M.

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Title Statements

Full title :Biologic foundations for skeletal tissue engineering / Ericka M. Bueno, Julie Glowacki.

Summary

Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients.

Edition Statements

Publication Date:©2011.

Publication Statements

Publisher(s):Morgan & Claypool
Place of Publication:San Rafael, Calif
Language:eng
Publication Date:©2011.

Notes

Titre de l'écran-titre (visionné le 23 mars 2012).

1. Introduction

The Physical Object

Description:1 ressource en ligne (1 texte électronique (viii, 210 pages)) : : illustrations, fichier PDF

Edition Identifiers

ISBN:9781608451739, 1608451739
DOI:10.2200/S00329ED1V01Y201101TIS007
oclc:on1132095522
LC Classification:R857.T55
Dewey Decimal:610.28

2. Structure and function of bone and cartilage tissue -- Bone -- Structure -- Function -- Mechanical properties -- Articular cartilage -- Structure -- Function -- Mechanical properties

3. Development -- Intramembranous bone formation -- Endochondral bone formation -- Articular cartilage

4. Responses to injury and grafting -- Bone -- Microfractures -- Bone fractures -- Fracture healing -- Distraction osteogenesis -- Comparison of post-natal fracture healing and skeletal embryogenesis -- Bone grafts, implants, and bone substitute materials -- Cartilage

5. Clinical applications for skeletal tissue engineering -- Disorders in bone -- Focal deficiencies -- Systemic disorders of bone -- Cartilage -- Osteoarthritis -- Rheumatoid arthritis -- Osteochondritis dissecans -- Temporomandibular joint (TMJ) disorders

6. Animal models -- Bone -- Biocompatibility -- Osteocompatibility -- Bone substitutes -- Clinical relevance -- Cartilage

7. Tissue engineering principles for bone and cartilage -- Bone -- Scaffolds -- Bioactive factors -- Cells -- In vitro studies -- In vivo studies -- Cartilage -- Scaffolds -- Bioactive factors -- Cells -- In vitro studies -- In vivo studies

8. Perspectives…