Bioorganometallic Chemistry

An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term ""bioorganometallics"", and his international team of experts have put together a valuable resource for research.

Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging; Contents; List of Contributors; Preface; Part One: Medicinal Chemistry; 1. Organometallic Complexes as Enzyme Inhibitors: A Conceptual Overview; 1.1 Introduction; 1.2 Organometallic Compounds as Inert Structural Scaffolds for Enzyme Inhibition; 1.3 Organometallic Compounds Targeting Specific Protein Residues; 1.4 The Bioisosteric Substitution; 1.5 Novel Mechanisms of Enzyme Inhibition with Organometallic Compounds; 1.6 Organometallic Compounds as Cargo Delivers of Enzyme Inhibitors.

1.7 Organometallic Enzyme Inhibitors for Theranostic Purposes1.8 Conclusion; Acknowledgments; Abbreviations; References; 2. The Biological Target Potential of Organometallic Steroids; 2.1 Introductory Note on Nuclear Receptors; 2.1.1 Early History; 2.1.2 Primary Structure of Nuclear Receptors; 2.1.3 Estrogen Receptors; 2.1.4 Androgens; 2.1.5 Glucocorticoids; 2.1.6 Progesterone and Progestogens; 2.1.7 Mineralocorticoids and Aldosterone; 2.1.8 Selective Modulators of Nuclear Receptors; 2.1.8.1 Selective Estrogen Receptor Modulators (SERMs); 2.1.8.2 Selective Androgen Receptor Modulators (SARMs).

2.2.4 Approach Towar…