Bone morphogenetic proteins: systems biology regulators
by Sampath, Kuber T. Vukicevic, Slobodan
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit …
Read More ↓Title Statements
- Full title :Bone morphogenetic proteins : systems biology regulators / Slobodan Vukicevic, Kuber T. Sampath, editors.
Summary
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
Read More ↓Edition Statements
- Publication Date:2017.
Publication Statements
- Publisher(s):Springer
- Place of Publication:Cham, Switzerland
- Language:eng
- Publication Date:2017.
Notes
Includes index.
The Physical Object
- Description:1 online resource (xii, 445 pages) : : illustrations (some color)
Edition Identifiers
- ISBN:9783319475073, 331947507X
- DOI:10.1007/978-3-319-47507-3
- oclc:ocn976406573
- LC Classification:QP552.B65
- Dewey Decimal:612.7/51
Table of Contents
Preface; Contents; List of Contributors; Historical Perspective of€Bone Morphogenetic Proteins; 1 Bone Formation: Auto-induction; 2 Matrix-Induced Bone Formation: A€Biological Cascade; 3 Discovery of€Bone Morphogenetic Proteins; 4 BMP Structure; 5 BMP Receptors; 6 BMP Preclinical Studies; 7 BMP-7 in€Articular Cartilage Repair; 8 BMPs Beyond Bone; 9 BMP Clinical Studies; 10 Conclusion; References; The Systems Biology of€Bone Morphogenetic Proteins; 1 BMPs During Development; 2 Structure and€Function; 3 BMP: In€Vitro and€In€Vivo Model Systems for€Endochondral Bone Differentiation.
4 Role of€BMPs in€Cartilage Repair and€Regeneration5 Role of€BMPs in€Bone Repair and€Regeneration; 6 BMPs in€Dentin Repair and€Regeneration; 7 BMP-7 in€Acute and€Chronic Kidney Failure; 8 BMPs in€Glucose Homeostasis; 9 BMP-7 and€Calcium and€Phosphate Homeostasis; 10 BMPs in€Iron Homeostasis; 11 BMPs' Role in€Rare Genetic Disorders; 12 BMP in€Oncology; 13 Conclusion; References; Embryonic Skeletogenesis and€Craniofacial Development; 1 Introduction; 2 Embryonic Skeletogenesis; 2.1 Developmental Stages of€Ossification; 2.2 BMP and€Osteogenesis; 2.3 Functional Studies in€Animal Models.
2.3.1 BMP and€Osteobla…
Subjects
Writers
More from this Series
No reviews yet. Be the first to rate this work.
Related Works
more →
Genetics
Functional performance in older adults
Methods in cell physiology
After extinction
Progress in nucleic acid research and molecular biology
Files & Downloads
-
Bone Morphogenetic Proteins: Systems Biology Regu…
PDF · 10.5 MB · updated
Rate & Review