Bone morphogenetic proteins

by Sampath, Kuber T. Vukicevic, Slobodan

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Title Statements

Full title :Bone morphogenetic proteins. / Slobodan Vukicevic, Kuber T. Sampath, editors.

Summary

This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

Edition Statements

Publication Date:2017

Publication Statements

Publisher(s):Springer
Place of Publication:Cham, Switzerland
Language:eng
Publication Date:2017

The Physical Object

Description:xii, 445 pages : : illustrations.

Edition Identifiers

ISBN:9783319475059, 3319475053, 331947507X, 9783319475073
oclc:ocn958460479
LC Classification:QR180-189.5
Dewey Decimal:616.71061

Historical perspective of bone morphogenetic proteins -- The systems biology of bone morphogenetic proteins -- Embryonic skeletogenesis and craniofacial development -- BMP and BMP regulation: structure and function -- Novel in vitro assay models to study osteogenesis and chondrogenesis for human skeletal disorders -- Toward advanced therapy medicinal products (ATMPs) combining bone morphogenetic proteins (BMP) and cells for bone regeneration -- BMP signaling in articular cartilage repair and regeneration: potential therapeutic opportunity for osteoarthritis -- BMPs in orthopaedic medicine: promises and challenges -- Osteogrow: a novel graft substitute for orthopedic reconstruction -- Biology of spine fusion and application of osteobiologics in spine surgery -- BMPs in dental medicine: promises and challenges -- Bone morphogenetic protein-7 and its role in acute kidney injury and chronic kidney failure -- Bone morphogenetic protein signaling in pulmonary arterial hypertension -- BMP signaling in fibrodysplasia ossificans progressiva, a rare genetic disorder of heterotopic ossification -- The central role of BMP signaling in regulating iron homeostasis -- BMPs in inflammation -- Phy…

Subjects

Allergy and Immunology Biologie systémique Bone Morphogenetic Proteins -- physiolo… Cell Biology Charts cytokines Cytologie Cytology Facteurs de croissance growth factors Growth Substances Immunologie Immunology Médecine Medicine medicines (material) protein Protéines Proteins Signal Transduction -- physiology