Breast pathology: problematic issues

This book covers practical diagnostic issues in breast pathology, with special emphasis on areas which pose diagnostic difficulties. These include dealing with the gross specimens derived from patients treated with conservative surgery and those who had neo-adjuvant therapy before surgery. It also discusses how to deal with axillary lymph nodes, proliferative breast lesions, including DCIS, and problematic core biopsies, as well as fibro-epithelial, spindle cell, lobular, mucinous, metaplastic and papillary lesions, molecular classification of breast cancers, breast lesions in male patients and breast immunohistochemistry. There is a focus on unusual benign and malignant breast lesions and a large number of high-quality images help the reader diagnose difficult cases. Breast Pathology: Problematic Issues is aimed at histopathology consultants and senior trainees who deal with breast pathology.

Introduction; Contents; Contributors; 1: Dealing with€the€Gross Specimen; Introduction; Core Biopsies; Dealing with€Specimens from€Conservative Surgery; Reporting Excision Margin Status; Lumpectomy Specimens; Mastectomy Specimens; Axillary Lymph Node Specimens and€Specimens Received After€Neoadjuvant Therapy; References; 2: Handling Neoadjuvant Therapy Specimens; Introduction; Pretreatment Diagnosis; Specimen Handling; Wide Local Excision Specimens; Mastectomies; Axillary Lymph Nodes; Histological Reporting; Breast; Axillary Lymph Nodes; Definition of€pCR.

Grading of€Response Retesting of€Tumor Markers Post-Ưneoadjuvant Therapy; Neoadjuvant Therapy and€Clinical Trials; References; 3: Proliferative Breast Lesions; Introduction; Ductal Lesions; Usual Epithelial Hyperplasia; Atypical Ductal Hyperplasia; Ductal Carcinoma In€Situ; Epithelial Proliferation (Hyperplasia, Atypia, and€DCIS) Within€Papillary Lesions; Paget's Disease of€the€Nipple; Lobular Lesions; Atypical Lobular Hyperplasia and€Classical Lobular Carcinoma In€Situ (In Situ Lobular Neoplasia); Columnar Cell Lesions; Columnar Cell Change and€Columnar Cell Hyperplasia.

Flat Epithelial AtypiaReferences; 4: Problematic Core B…