Brown adipose tissue
by Herzig, Stephan Klingenspor, Martin Pfeifer, Alexander
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Read More ↓Title Statements
- Full title :Brown adipose tissue / Alexander Pfeifer, Martin Klingenspor, Stephan Herzig, editors.
Summary
The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Read More ↓Edition Statements
- Publication Date:2019
Publication Statements
- Publisher(s):Springer
- Place of Publication:Cham, Switzerland
- Language:eng
- Publication Date:2019
The Physical Object
- Description:viii, 424 pages : : illustrations (some color) ; : 24 cm.
Edition Identifiers
- ISBN:9783030105129, 3030105121
- DOI:10.1007/978-3-030-10513-6
- oclc:on1098239771
- LC Classification:QP88.15
- Dewey Decimal:611/.018276
Table of Contents
Intro; Preface; Contents; Brown Adipose Tissue Development and Metabolism; 1 Introduction and Background; 1.1 Overview; 1.2 Basics of Non-shivering Thermogenesis; 1.3 Brown Fat Anatomy and Morphology; 1.4 BAT Vascularization and Innervation; 1.5 Transcriptional Control of Brown Adipocyte Differentiation; 2 Brown Fat Growth; 2.1 Techniques for Studying BAT Development; 2.1.1 FACS; 2.1.2 Lineage Tracing; 2.2 Brown Adipocyte Origins; 2.3 Postnatal and Adult Brown Fat Growth and Metabolism; 3 Other Thermogenic Adipocytes; 3.1 Brite/Beige Adipocytes; 3.2 Brite/Beige Adipocyte Origins
4 Going Forward4.1 Unanswered Questions and Future Goals; 4.2 Prospects for BAT-Based Therapeutics; References; Lessons from Cre-Mice and Indicator Mice; 1 Introduction; 2 Techniques to Create Transgenic Mouse Lines; 3 Tamoxifen Inducible vs. Dox-Inducible Recombinase Systems; 4 The ap2 Promoter; 5 The Adiponectin Promoter; 6 The Ucp1 Promoter; 7 Genetic Mouse Models to Disrupt Mature Brown Adipocyte Function; 8 Lessons from Fat but Non-brown Fat-Specific Gene Targeting and Tracing; 9 Indicator Mice of Brown Fat Function; 10 White/Brown/Brite Adipocyte-Specific Labeling; References
Aging of Brown and Bei…
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