Cancer Cell Signalling

A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a 'must-have' for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.

Cover; Title Page; Copyright; Contents; List of contributors; Acknowledgements; Introduction; About the companion website; Chapter 1 Epidermal growth factor receptor family; 1.1 ErbB receptors and their structure; 1.2 ErbB ligands; 1.2.1 Ligand production; 1.2.2 Effects of ligand binding to receptors; 1.3 Downstream signalling molecules and events; 1.4 Signalling regulation; 1.4.1 Regulation of phosphorylation events; 1.4.2 Internalisation of receptors; 1.5 Dysregulation of signalling in cancer; 1.5.1 Receptor over-expression; 1.5.2 Activating mutations; 1.5.3 Altered cellular localisation

1.5.4 Changes in ligand levels1.5.5 Changes in adaptor protein levels; 1.6 Therapeutic opportunities; 1.6.1 Current strategies; 1.6.2 Future strategies; References; Chapter 2 Insulin and the insulin-like growth factor (IGF) family; 2.1 Receptors; 2.2 Ligands; 2.2.1 Types of ligands; 2.2.2 Ligand binding affinities; 2.2.3 Insulin growth factor binding proteins (IGFBPs); 2.3 Downstream signalling molecules and events; 2.4 Dysregulation of signalling in cancer; 2.4.1 Over-expression and activation of receptors; 2.5 Therapeutic opportunities; 2.5.1 Targeting receptors; 2.5.2 Targeting ligands

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