Capillary electrophoresis: trends and developments in pharmaceutical research

"Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis. "--Provided by publisher.

Cover; Half Title; Title; Copyright; Contents; Preface; Chapter 1. Capillary Electrophoresis: A Versatile Technique in Pharmaceutical Analysis Imran Ali, Zeid A. Alothman, Abdulrahman Alwarthan, and Hassan Y. Aboul-Enein ; 1.1 Introduction; 1.2 Theory of Capillary Electrophoresis; 1.3 Types of Capillary Electrophoresis; 1.4 Instrumentation; 1.4.1 Sample Introduction; 1.4.2 Capillary Electrophoresis Capillary; 1.4.3 Power Supply; 1.4.4 Background Electrolyte; 1.4.5 Detection; 1.4.5.1 UV/Vis absorbance detectors; 1.4.5.2 Conductivity detectors; 1.4.5.3 Amperometric detectors

1.4.5.4 Thermooptical absorbance detectors1.4.5.5 Fluorescence detectors; 1.4.5.6 Atomic absorption spectroscopy detectors; 1.4.5.7 Inductively coupled plasma detectors; 1.4.5.8 Mass detectors; 1.4.5.9 Miscellaneous detectors; 1.4.5.10 Indirect detection; 1.5 Data Integration; 1.6 Sample Preparation; 1.7 Method Development and Optimization; 1.8 Validation of Methods; 1.9 Applications; 1.10 Conclusion ; Chapter 2. Recent Applications of Chiral Capillary Electrophoresis in Pharmaceutical Analysis José María Saz and María Luisa Marina ; 2.1 Introduction

2.2 Chiral Selectors Added to BGE for Enantioseparation of C…