Capturing chromosome conformation: methods and protocols

by Bodega, Beatrice Lanzuolo, Chiara

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Title Statements

Full title :Capturing chromosome conformation : methods and protocols / edited by Beatrice Bodega, Chiara Lanzuolo.

Summary

Tridimensional chromatin conformation has emerged nowadays as a fundamental layer of epigenetic regulation of cell identity and plasticity. Indeed, the genome is spatially ordered in compartments and topologically associated domains, and the multiple levels of DNA folding generate contacts between different genomic regions that may involve chromatin loops formation. The field is evolving rapidly, together with a plethora of sophisticated novel technologies based on next generation sequencing and advanced microscopy to capture the higher order chromatin structure and its functional changes in cellular processes and diseases. This collection represents our updated comprehension of methods based on the evolution of chromosome conformation capture (3C) technique and other complementary approaches to dissect chromatin conformation with an emphasis on dissection of nuclear compartmentalization and visualization in imaging.

Edition Statements

Publication Date:2021

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York, NY
Language:eng
Publication Date:2021

The Physical Object

Description:1 online resource (xi, 322 pages)) : : illustrations.

Edition Identifiers

ISBN:9781071606643, 1071606646, 9781071606650, 1071606654, 9781071606667, 1071606662
DOI:10.1007/978-1-0716-0664-3.
oclc:on1245158771
LC Classification:QH324
Dewey Decimal:570.28

Subjects

Biologie -- Technique Biology -- Technique Cell Biology Chromatin Chromatine Cytologie Cytology Genetics Génétique Laboratory Manual Laboratory manuals Manuels de laboratoire Protein Conformation Protéines -- Conformation Proteins -- Conformation