Chromosomal instability and aging

Chromosomal instability and aging: basic science and clinical implications

by Hisama, Fuki M. Martin, George M. Weissman, Sherman M.

Type Book
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This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage.

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Title Statements

  • Full title :Chromosomal instability and aging : basic science and clinical implications / edited by Fuki M. Hisama, George M. Martin.

Summary

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage.

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Edition Statements

  • Publication Date:©2003.

Publication Statements

  • Publisher(s):Marcel Dekker
  • Place of Publication:New York
  • Language:eng
  • Publication Date:©2003.

The Physical Object

  • Description:1 online resource (xviii, 579 pages) : : illustrations (some color)

Edition Identifiers

  • ISBN:0824747305, 9780824747305, 9780203911709, 0203911709
  • oclc:ocm52854788
  • LC Classification:QP86
  • Dewey Decimal:612.6/7

Table of Contents

Foreword; Preface; Contents; Contributors; Introduction; Overview of Chromosomal Instability and Aging Mechanisms; Cellular Senescence; Telomeric Shortening and Replicative Aging; Telomeric Regulation in Eukaryotic Cells; Role of Ku at the Telomere; Chromosomal Instability in Normative Aging; Chromatin, Aging, and Cellular Senescence; Werner Syndrome; Bloom Syndrome: Genetic, Cellular, and Molecular Features as Compared to Werner Syndrome; Molecular Biology of Rothmund-Thomson Syndrome; Hutchinson-Gilford Progeria Syndrome; Ataxia-Telangiectasia; Nijmegen Breakage Syndrome.

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