Classics in total synthesis

"Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists."--Résumé de l'éditeur pour le volume 3

"Nowadays, books that concentrate on the area of organic synthesis are numerous enough to fill whole inventories of libraries. But of that multitude, only a few books have been as outstanding in recent years as the series Classics in Total Synthesis, written by K.C. Nicolaou with various co-authors. This series can therefore already be justifiably called a classic in itself. Likewise, the third volume of this series, published by Wiley-VCH in February 2011, will surely continue the success of the previous volumes, and will certainly be a must-have in the libraries of synthetically orientated groups. The concept of the preceding volumes has been closely retained. In 26 chapters, including an introductory chapter, syntheses of more than 40 natural products or natural product core structures are discussed in detail. The syntheses, together with historical excursions, have been taken from literature of the years 2003 to 2010. Each chapter begins with background information about the discovery, structure elucidation, and biological significance of the target molecule(s). To aid the reader_s orientation, key concepts of the total synthesis described are provided at the beginning of each chapter. After describing retrosyntheses that have been achieved, and any preliminary synthetic work, the chapter gives a very detailed description of the synthesis of the target structure, including almost all the individual steps. All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. The chapter ends with a short summary and a well-chosen, detailed, and extensive list of references. This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the solution of his or her own synthetic problems."--Résumé de l'éditeur pour le volume 3

Le volume 2 comprend un CD-ROM.

"A CD with useful teaching material for lecturer"--Page 4 de la couverture du volume 2

"This volume completes a trilogy in the Classics in total synthesis series. It provides an overview of the state of the art in total synthesis, with an emphasis on the strategies and tools employed to construct complex molecules."--Préface du volume 3

"About the authors : K.C. Nicolaou holds joint appointments at The Scripps Research Institute, where he is the chairman of the department of chemistry and holds the Darlene Shiley Chair in Chemistry and the Aline W. and L.S. Skaggs Professorship of Chemical Biology, and the University of California, San Diego, where he is Distinguished Professor of Chemistry. Jason S. Chen received his A.B. and A.M. degrees in Chemistry from Harvard University in 2001. After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.C. Nicolaou."--Page xi et xii du volume 3

Vol. 2. More targets, strategies, methods / K.C. Nicolaou and S.A. Snyder, c2003. -- vol. 3. Further targets, strategies, methods / K.C. Nicolaou, Jason S. Chen, c2011.