Clinical epidemiology: practice and methods

by Barrett, Brendan J. Parfrey, Patrick S.

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Title Statements

Full title :Clinical epidemiology : practice and methods / edited by Patrick S. Parfrey and Brendan J. Barrett.

Summary

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system.

Edition Statements

Publication Date:2021
Edition:Third edition

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York, NY
Language:eng
Publication Date:2021

The Physical Object

Description:1 online resource (xiii, 650 pages) : : illustrations (some color)

Edition Identifiers

ISBN:9781071611388, 1071611380
DOI:10.1007/978-1-0716-1138-8
oclc:on1247900379
LC Classification:RA652
Dewey Decimal:614.4

On Framing the Research Question and Choosing the Appropriate Research Design -- Bias in Clinical Research -- Definitions of Bias in Clinical Research -- Research Ethics for Clinical Researchers -- Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research -- Longitudinal Studies 1: Determinants of Risk -- Longitudinal Studies 2: Modeling Data using Multivariate Analysis -- Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions -- Longitudinal Studies 4: Matching Strategies to Evaluate Risk -- Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease -- Randomized Controlled Trials 1: Design -- Randomized Controlled Trials 2: Analysis -- Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes -- Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies -- Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes -- Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies -- Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect -- Evalu…