Clinical genomics

by Kulkarni, Shashikant Pfeifer, John D.

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Title Statements

Full title :Clinical genomics / edited by Shashikant Kulkarni, John Pfeifer.

Edition Statements

Publication Date:2015

Publication Statements

Publisher(s):Elsevier/Academic Press
Place of Publication:Amsterdam
Language:eng
Publication Date:2015

The Physical Object

Description:1 online resource (xvii, 470 pages :) : illustrations.

Edition Identifiers

ISBN:9780124047488, 0124047483
oclc:on1340096308

Machine generated contents note: I.Methods -- 1.Overview of Technical Aspects and Chemistries of Next-Generation Sequencing / Ian S. Hagemann -- Clinical Molecular Testing: Finer and Finer Resolution -- Sanger Sequencing -- Cyclic Array Sequencing -- Illumina Sequencing -- SOLiD Sequencing -- Ion Torrent Sequencing -- Roche 454 Genome Sequencers -- Third-Generation Sequencing Platforms -- References -- 2.Clinical Genome Sequencing / Erica Ramos -- Introduction -- Applications and Test Information -- Laboratory Process, Data Generation, and Quality Control -- Conclusion -- References -- 3.Targeted Hybrid Capture Methods / Elizabeth C. Chastain -- Introduction -- Basic Principles of Hybrid Capture-Based NGS -- Hybrid Capture-Based Target Enrichment Strategies -- Clinical Applications of Target Capture Enrichment -- Variant Detection -- Practical and Operational Considerations -- Conclusions -- References -- 4.Amplification-Based Methods / Yuri E. Nikiforov -- Introduction

Note continued: Principles of Amplification-Based Targeted NGS -- Nucleic Acids Preparation -- Primer Design for Multiplex PCR -- Library Preparation and Amplification -- Other Amplification-Based Target Enrichmen…