Clinical trial optimization using R

by Dmitrienko, Alex Pulkstenis, Erik

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Title Statements

Full title :Clinical trial optimization using R / edited by Alex Dmitrienko, Erik Pulkstenis.

Edition Statements

Publication Date:2017

Publication Statements

Publisher(s):CRC Press
Place of Publication:Boca Raton, FL
Language:eng
Publication Date:2017

The Physical Object

Description:xvii, 319 pages ; : 24 cm

Edition Identifiers

ISBN:9781498735070, 149873507X
oclc:ocn966436484
LC Classification:R853.C55
Dewey Decimal:610.72/7

Machine generated contents note: 1.Clinical Scenario Evaluation and Clinical Trial Optimization / Gautier Paux -- 1.1.Introduction -- 1.2.Clinical Scenario Evaluation -- 1.2.1.Components of Clinical Scenario Evaluation -- 1.2.2.Software implementation -- 1.2.3.Case study 1.1: Clinical trial with a normally distributed endpoint -- 1.2.4.Case study 1.2: Clinical trial with two time-to-event endpoints -- 1.3.Clinical trial optimization -- 1.3.1.Optimization strategies -- 1.3.2.Optimization algorithm -- 1.3.3.Sensitivity assessments -- 1.4.Direct optimization -- 1.4.1.Case study 1.3: Clinical trial with two patient populations -- 1.4.2.Qualitative sensitivity assessment -- 1.4.3.Quantitative sensitivity assessment -- 1.4.4.Optimal selection of the target parameter -- 1.5.Tradeoff-based optimization -- 1.5.1.Case study 1.4: Clinical trial with an adaptive design -- 1.5.2.Optimal selection of the target parameter -- 2.Clinical Trials with Multiple Objectives / Gautier Paux

Note continued: 2.1.Introduction -- 2.2.Clinical Scenario Evaluation framework -- 2.2.1.Data models -- 2.2.2.Analysis models -- 2.2.3.Evaluation models -- 2.3.Case study 2.1: Optimal selection of a multiplicity adjus…

Subjects

Clinical trials -- Statistical methods Clinical Trials as Topic Études cliniques -- Méthodes statistiqu… Langages de programmation programming languages Programming languages (Electronic compu… R (Computer program language) R (Langage de programmation)