Clinical Trial Optimization Using R.

by Dmitrienko, Alex

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Title Statements

Full title :Clinical Trial Optimization Using R.

Edition Statements

Publication Date:©2017
Edition:1st ed

Publication Statements

Publisher(s):CRC Press
Place of Publication:Portland
Language:eng
Publication Date:©2017

The Physical Object

Description:1 online resource (338 pages).

Edition Identifiers

ISBN:9781498735087, 1498735088
oclc:on1041146146
LC Classification:R853.C55
Dewey Decimal:610.727

Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- List of Contributors -- 1: Clinical Scenario Evaluation and Clinical Trial Optimization -- 1.1 Introduction -- 1.2 Clinical Scenario Evaluation -- 1.2.1 Components of Clinical Scenario Evaluation -- 1.2.2 Software implementation -- 1.2.3 Case study 1.1: Clinical trial with a normally distributed endpoint -- 1.2.4 Case study 1.2: Clinical trial with two time-to-event endpoints -- 1.3 Clinical trial optimization -- 1.3.1 Optimization strategies -- 1.3.2 Optimization algorithm -- 1.3.3 Sensitivity assessments -- 1.4 Direct optimization -- 1.4.1 Case study 1.3: Clinical trial with two patient populations -- 1.4.2 Qualitative sensitivity assessment -- 1.4.3 Quantitative sensitivity assessment -- 1.4.4 Optimal selection of the target parameter -- 1.5 Tradeoff-based optimization -- 1.5.1 Case study 1.4: Clinical trial with an adaptive design -- 1.5.2 Optimal selection of the target parameter -- 2: Clinical Trials with Multiple Objectives -- 2.1 Introduction -- 2.2 Clinical Scenario Evaluation framework -- 2.2.1 Data models -- 2.2.2 Analysis models -- 2.2.3 Evaluation models -- 2.3 Case study 2.1: Optim…