Clinical trials: a methodologic perspective

by Piantadosi, Steven

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Title Statements

Full title :Clinical trials : a methodologic perspective / Steven Piantadosi.

Edition Statements

Publication Date:©2017
Edition:Third edition

Publication Statements

Publisher(s):John Wiley & Sons, Inc
Place of Publication:Hoboken, NJ
Language:eng
Publication Date:©2017

The Physical Object

Description:xxviii, 886 pages ; : 27 cm.

Edition Identifiers

ISBN:9781118959206, 1118959205
oclc:ocn964437412
LC Classification:R853.C55
Dewey Decimal:610.72/4

Preliminaries -- Clinical Trials as research -- Why Clinical Trials are ethical -- Context for Clinical Trials -- Context for clinicak tricals -- Measurement -- Random error and bias -- Statistical perspectives -- Experiment design in clinical trials -- The trial cohort -- Development paradigms -- Translational clinical trials -- Early development and dose-finding -- Middle Development -- Comparative trials -- Adaptive design features -- Sample size and power -- Treatment allocation -- Treatment effects monitoring -- Counting subjects and events -- Estimating clinical effects -- Prognostic factor analyses -- Factorial design -- Crossover Designs -- Meta-analyes -- Reporting and authorship -- Misconduct and fraud in clinical research -- Appendix A Data and programs -- Appendix B Abbreviations -- Appendix C Notation and Terminology -- Appendix D Nuremberg code -- References -- Index.

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