Comprehensive Toxicology

An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ.

1.09.3 Methodological Advances for Assessing Toxicology of Chemical Mixtures.

E9780080468686v1; Cover; Comprehensive Toxicology; Copyright; Contents of Volume 1; Contents of All Volumes; Preface; 1.01 General Overview of Toxicology; Abbreviations; 1.01.1 Introduction; 1.01.2 Concepts of Absorption, Distribution, Metabolism, and Excretion; 1.01.3 Types of Toxic Effect; 1.01.4 Toxicity Testing in Experimental Animals; 1.01.5 Risk Assessment and Regulatory Toxicology; References; 1.02 Exposure Science; 1.02.1 Introduction; 1.02.2 Basic Principles of Exposure Science; 1.02.3 Methodologies; 1.02.4 Environmental Media and Routes of Exposure; 1.02.5 Biological Markers.

1.02.6 Data Analysis and Models1.02.7 Exposure Modeling; 1.02.8 Uncertainties; 1.02.9 Conclusion; Acknowledgments; References; 1.03 Oral Exposure and Absorption of Toxicants; Abbreviations; 1.03.1 Anatomy and Physiology of the Gastrointestinal Tract; 1.03.2 The Process and Kinetics of Oral Absorption; 1.03.3 Dose and Dose-Rate Effects; 1.03.4 Factors Affecting Oral Absorption; 1.03.5 Gastrointestinal Metabolism; 1.03.6 Conclusion; References; 1.04 Inhalation Exposure and Absorption of Toxicants; Abbreviations; 1.04.1 Key Terms and Concepts in Inhalation Toxicokinetics.

1.04.2 Deposition of Inhaled…