Title Statements
- Full title :Conn's handbook of models for human aging / editors, Jeffrey L. Ram, P. Michael Conn.
Edition Statements
- Publication Date:2018
- Edition:Second edition
Publication Statements
- Publisher(s):Academic Press, Elsevier Ltd
- Place of Publication:London, United Kingdom
- Language:eng
- Publication Date:2018
Notes
Includes index.
The Physical Object
- Description:1 online resource
Edition Identifiers
- ISBN:9780128113547, 0128113545
- oclc:on1031373801
- LC Classification:QP86
- Dewey Decimal:612.6/7
Table of Contents
Intro; Title page; Table of Contents; Copyright; List of Contributors; Preface; Preface; Section I. Aging in Humans; Chapter 1. Werner Syndrome as a Model of Human Aging; Introduction and Historical Overview; Werner Syndrome as a Clinical Disease; Cancer in Werner Syndrome; Clinical Progression of Werner Syndrome; Diagnostic Criteria and Differential Diagnosis; The WRN Gene and Disease-Associated Mutations; Atypical WS/Other Heritable Progeroid Syndromes Distinct From WS; WRN Protein Function in Human Cells; The Relationship of Werner Syndrome to Normal Aging.
Experimental Models of Werner SyndromePotential Therapeutic Targets and Strategies; Concluding Remarks; Print Resources; Web Resources; Chapter 2. Premature Aging Syndrome; Introduction; Hutchinson-Gilford Progeria and Werner Syndrome; Causative Genes and Molecular Mechanisms; Management and Therapeutic Approaches; Cell Culture Models; Mouse Models; Conclusions; Chapter 3. Models, Definitions, and Criteria for Frailty; Introduction; Models and Mechanisms; Definition; Criteria; Conclusion; Recommended Resources.
Chapter 4. Immunological Methods and the Concept of Inflammaging in the Study of Human AgingIntroduction; Phenoty…
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