Cytomegaloviruses: from molecular pathogenesis to intervention

Human Cytomegalovirus (CMV) - a member of the herpesvirus family - is an underrated health risk. A low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune systems are intact, with primary infection usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with lifelong neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immune compromised patients requiring either a solid organ gr.

II. 1. Synopsis of Clinical Aspects of Human Cytomegalovirus Disease / William J. Britt -- II. 2. The Epidemiology and Public Health Impact of Congenital Cytomegalovirus Infection / Karen B. Fowler -- II. 2. Addendum / Sheila C. Dollard -- II. 3. Clinical Cytomegalovirus Research: Congenital Infection / Giovanni Nigro -- II. 4. Cytomegalovirus Replication in the Developing Human Placenta / June Fang-Hoover -- II. 5. The Guinea Pig Model of Congenital Cytomegalovirus Infection / Mark R. Schleiss -- II. 6. Murine Model of Neonatal Cytomegalovirus Infection / Stipan Jonjic -- II. 7. Adaptive Cellular Immunity to Human Cytomegalovirus / J.G. Patrick Sissons -- II. 8. Natural Killer Cells and Human Cytomegalovirus / Eddie C.Y. Wang -- II. 9. Innate Immunity to Cytomegalovirus in the Murine Model / Stipan Jonjic -- II. 10. Protective Humoral Immunity / Thomas Winkler.

Contents note continued: II. 11. Immunoregulatory Cytokine Networks Discovered and Characterized during Murine Cytomegalovirus Infections / Christine A. Biron -- II. 12. Host Genetic Models in Cytomegalovirus Immunology / Marc Dalod -- II. 13. Clinical Cytomegalovirus Research: Thoracic Organ Transplantation / Robin K. Av…