Developmental Toxicology, Third Edition

by Hansen, Deborah K.

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Title Statements

Full title :Developmental Toxicology, Third Edition.

Summary

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes.

Edition Statements

Publication Date:©2008.
Edition:3rd ed

Publication Statements

Publisher(s):CRC Press
Place of Publication:New York
Language:eng
Publication Date:©2008.

The Physical Object

Description:1 online resource (496 pages).

Edition Identifiers

ISBN:9781420054385, 1420054384
oclc:on1058923562
LC Classification:RA1224.45.D47 2009eb
Dewey Decimal:618.3

Front Cover -- Title Page -- Preface -- Contents -- Chapter 1- Role of Apoptosis in Normal and Abnormal Development -- Chapter 2- Signal Transduction Pathways as Targets for Teratogens -- Chapter 3- Nutrition in Developmental Toxicology -- Chapter 4- Epigenetic Mechanisms: Role of DNA Methylation, Histone Modifications, and Imprinting -- Chapter 5- Personalized Nutrition and Medicine in Perinatal Development -- Chapter 6- Targeted Gene Changes Affecting Developmental Toxicity -- Color Inserts -- Chapter 7- Use of Mammalian In Vitro Systems, Including Embryonic Stem Cells, in Developmental Toxicity Testing -- Chapter 8- Zebrafish: A Nonmammalian Model of Developmental Toxicology -- Chapter 9- Physiologically Based Pharmacokinetic Modeling in the Risk Assessment of Developmental Toxicants -- Chapter 10- Integration of Whole Animal Developmental Toxicity Data into Risk Assessment -- Chapter 11- Genomic Approaches in Developmental Toxicology -- Chapter 12- Comparative Bioinformatics and Computational Toxicology -- Chapter 13- Investigating Drug Effects in Human Pregnancy -- Index -- Back Cover.

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