DNA In Forensic Science: Theory, Techniques And Applications

Structure; function and variation in DNA; DNA in the cell; experimental techniques in the examination and analysis of DNA; hypervariant probes in DNA analysis; intermediate variant probes; unique sequence or single locus probes; affiliations of PCR in forensic analysis; DNA analysis in paternity testing; DNA profiling - a legal perspective; current status; future prospects.

Title -- Copyright -- Table of contents -- Introduction -- DNA as the chemical of heredity -- The structure of DNA -- Biological consequences of DNA structure -- DNA in cells -- DNA sequencing -- Gene definition and function -- Protein structure and function -- From gene to gene product -- The genetic code -- Some genes of interest -- The number and distribution of genes -- Non-coding DNA, mobile genetic elements, and retroviruses -- Selfish DNA -- Genetical variation -- Conclusions -- Acknowledgements -- Introduction -- Chromosomes and tissues -- The observable chromosome -- The interaction of DNA and the histone-proteins of the chromosome -- The lowest level of structure of normal human chromatin -- Transcriptionally active chromatin -- The principles behind the extraction of DNA from somatic cells -- Chromatin disruption for DNA preparation -- the problems -- Premature proteolysis -- Summary: a 'typical' DNA extraction procedure -- The principles behind extraction of DNA from sperm chromatin -- Patterns of nucleolytic damage of sperm chromatin -- Non-enzymic chemical damage of DNA during DNA and chromatin isolation procedures -- References -- Introduction -- Effect of the envir…