Genetic susceptibility to infectious diseases

Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. This text uniquely focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1, and deals systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. Section 3 provides a meaningful picture of how these genes operate in infectious disease.

I. Methods and Tools -- 1. Genetic Epidemiology of Infectious Disease / Priya Duggal and Terri H. Beaty -- 2. Laboratory Analysis of Genetic Variation / Meredith Yeager, Robert A. Welch and Stephen J. Chanock -- 3. Mouse Models for Genetic Susceptibility to Infection in Humans / Anny Fortin, Ellen Buschman and Emil Skamene -- II. Immune Response Genes and Infection -- 4. MHC Class I and Related Genes / Henry A. F. Stephens -- 5. MHC Class II and Related Genes / Janet M. McNicholl, Peter E. Jensen and Jeremy M. Boss -- 6. MHC Class I Polypeptide-Related Sequence A and B (MICA and MICB) Genes / Seiamak Bahram -- 7. Killer Immunoglobulin-Like Receptor and Related Genes / Maureen P. Martin, M. Tevfik Dorak and Mary Carrington -- 8. Red Blood Cell Genes and Malaria / David Weatherall -- 9. Immunoglobulin (Fc) and Related Receptor Genes / Jennifer A. Croker and Robert P. Kimberly -- 10. Mannose-Binding Lectin Genes / Richard Bellamy -- 11. Complement Genes / Keith D. Crawford and Chester A. Alper -- 12. Toll-Like Receptor Genes / Bruce Beutler -- 13. Metal Transport Genes / Jean-Francois Marquis, John R. Forbes, Francois Canonne-Hergaux, Cynthia Horth and Philippe Gras -- 14. Tumor Necr…