Genetics of Complex Disease

by Donaldson, Peter

Type Book

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Title Statements

Full title :Genetics of Complex Disease

Edition Statements

Publication Date:2015.

Publication Statements

Publisher(s):Taylor & Francis Group
Place of Publication:New York
Language:eng
Publication Date:2015.

Notes

Polygenic complex diseases involve many risk alleles

The Physical Object

Description:1 online resource (429 pages)

Edition Identifiers

ISBN:9781317334255, 1317334256, 9780429258688, 0429258682, 9780815344919, 0815344910
oclc:on1130902426
LC Classification:RB155
Dewey Decimal:616/.042

Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- Acknowledgments -- Chapter 1: Genetic Diversity -- 1.1 Genetic Terminology -- The use of the terms genes and alleles varies, though they do have precise definitions -- 1.2 Genetic Variation -- Genetic variation can be measured by several methods -- Alleles on the same chromosome are physically linked and inherited as haplotypes -- Linkage disequilibrium promotes conservation of haplotypes in populations -- 1.3 Genetics and Evolution -- Mutation is the major cause of genetic variation

Genetic variation caused by mutation alters allele frequencies in populations -- Migration and dispersal cause gene flow -- Allele frequencies can change randomly via genetic drift -- The thrifty gene hypothesis -- Natural selection acting on different levels of fitness affects the gene pool -- 1.4 Calculating Genetic Diversity: Determining Population Variability -- Genotype and allele frequencies illustrate genetic diversity -- Allele frequency refers to the numbers of alleles present in a population -- Heterozygosity provides a quantitative estimation of genetic variation

The HWP is a complex but essential concept in pop…