Genomic medicine: a practical guide

"The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifically devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care. This text focuses on clinical utility and validity and serves as an 'owner's manual' in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference."--Provided by publisher

Pre-Analytics, Current Testing Technologies, and Limitations of Testing / Alejandro Luiña Contreras [and 4 others] -- Next Generation Sequencing / Alanna J. Church -- Cell-Free DNA Testing / Brennan Decker, Lynette M. Sholl -- Role of Bioinformatics in Molecular Medicine / Chad Vanderbilt, Sumit Middha -- Interpreting Genomic Reports / Alejandro Luiña Contreras -- Lung Carcinoma / Maria E. Arcila, Jason C. Chang, Laura J. Tafe -- GI including GIST / Efsevia Vakiani -- Breast / Dara S. Ross -- Genitourinary Tumors / Marie-Lisa Eich, George J. Netto -- Gynecologic Malignancies / Jessica L. Dillon, Laura J. Tafe -- Sarcomas / Konstantinos Linos -- Salivary Gland Carcinomas / Snjezana Dogan -- Sinonasal Carcinomas / Snjezana Dogan -- Acute Myeloid Neoplasms / Eric Y. Loo -- Chronic Myeloid Neoplasms / Maria E. Arcila, Caleb Ho -- Lymphomas / Vignesh Shanmugam, Annette S. Kim.