Genomics: fundamentals and applications

This new text delivers a foundation for understanding the role of genomics in human health and in advances that promise to help improve the quality of human life. Unlike other works that focus mainly on toxico-genomic techniques, Genomics presents a overview of the field in three major sections: 1) fundamentals of genes and genome structure, function, expression, variations, and genomic technology platforms; 2) applications of genomics in drug discovery and drug development, safety evaluation, genomic database maintenance, mining, and analysis, food safety monitoring, and translational toxicogenomics; and 3) how regulatory agencies such as the FDA and EPA use genomic data in their safety evaluation.

Genes and genomes -- Fundamentals of structure-function analysis of Eukaryotic protein-coding genes / Supratim Choudhuri -- The eukaryotic genome: a brief overview of structure, function, and evolution / Supratim Choudhuri -- Epigenetic regulation of gene and genome expression / Supratim Choudhuri -- Principles of functional genomic analysis / Scott A. Jackson [and others] -- Applications of genomics -- Toxiogenomics in non-clinical safety studies: models of animal and human tissues to assess target organ ingury / Alison Vickers -- Mining of genome sequence databases to identify new targets for prostate and breast cancer therapy / Tapan K. Bera, Byungkook Lee -- Functional genomic approaches for studying genotoxicity and carcinogenesis / Ebru Caba, Jiri Aubrecht -- Human genomics in hypertension / Pei-an Betty Shih, Daniel T. O'Conner, Sushil K. Mahata -- Immunotoxicogenomics: gene expression and immunotoxiocology in the age of genomics / Dori R. Germolec [and others] -- Statistical methods for functional analysis of 'Omics experimental data / Zoltan Dezso [and others] -- Toxicogenomics data and databases / Jennifer Fostel -- Phenotypic microarray approaches to the study of prokar…