Hematology: basic principles and practice

This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Edition includes access to the complete contents of the book online, fully searchable. A multidisciplinary approach from a unique team of specialists delivers well-rounded guidance on every topic. "Red boxes" present the authors' unique personal strategies for diagnosis and treatment. An intuitively re-designed table of contents makes information easier than ever to find. Online access allows you to rapidly search the entire contents of the book. Regular online updates personally overseen by Dr. Hoffman keep you apprised of important new developments

Anatomy and physiology of the gene -- Genomic approaches to the study of hematologic science -- Protein synthesis, processing, and trafficking -- Protein degradation in cells -- Protein architecture: relationship of form and function -- Regulation of cellular response -- Control of cell division -- Cell death -- Pharmacogenomics and hematologic diseases -- Overview and compartmentalization of the immune system -- B-cell development -- T-cell immunity -- Natural killer cell immunity -- Dendritic cell biology -- Regulation of activation of B and T lymphocytes -- Cell adhesion -- Cell trafficking and chemokines -- Tolerance and autoimmunity -- Overview of stem cell biology -- Cellular biology of hematopoiesis -- Transcription factors in normal and malignant hematopoiesis -- Nonhematopoietic stem cells originating within the bone marrow -- Interactions between hematopoietic stem/progenitor cells and the bone marrow: the biology of stem cell homing and mobilization -- The humoral regulation of hematopoiesis -- Biology of erythropoiesis, erythroid differentiation, and maturation -- Granulocytopoiesis and monocytopoiesis -- Thrombocytopoiesis -- Inherited forms of bone marrow failure -- …