Hemostasis and thrombosis: basic principles and clinical practice

"Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs"--Provided by publisher.

Part I: Introduction to the field of hemostasis and thrombosis. Coagulation enzymology -- Cell biology, protein processing, and cell signaling -- Cellular and molecular immunology -- Biostatistics and epidemiology: the basic science of clinical research -- Part II: Basic hemostasis and thrombosis. Coagulation & fibrinolysis -- Overview of basic coagulation and fibrinolysis -- The blood coagulation factors and inhibitors: complementary DNAs, genes and expression -- Genetics of coagulation proteins -- Tissue factor and the initiation and regulation (TFPI) of coagulation -- Factors V and VIII -- Structure and function of von Willebrand factor -- Structure and function of vitamin K-dependent coagulant and anticoagulant proteins -- Factor XI -- The Factor XII-driven plasma contact system -- Fibrinogen structure and function -- Factor XIII -- Antithrombin and the serpin family -- Protein C and S and thrombomodulin system -- Plasminogen activation and regulation of fibrinolysis -- Inhibitors of fibrinolysis -- Platelet biology -- Overview of platelet structure and function -- Platelet production: cellular and molecular regulation -- Megakaryocyte structure and platelet biogenesis -- Thro…