High Throughput Screening Methods

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This book serves as a practical reference for the current state of the art in high throughput screening, which remains a key part of early stage drug and tool compound discovery.

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Title Statements

Full title :High Throughput Screening Methods.

Summary

This book serves as a practical reference for the current state of the art in high throughput screening, which remains a key part of early stage drug and tool compound discovery.

Edition Statements

Publication Date:2016.

Publication Statements

Publisher(s):National Book Network International, Royal Society of Chemistry
Place of Publication:Place of publication not identified
Language:eng
Publication Date:2016.

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9781782626770, 1782626778
oclc:ocn965825566
LC Classification:RS419.5
Dewey Decimal:615.1/9

Cover; Contents; Foreword: Transforming Medicine by Innovating the Science of Therapeutics; Preface; Chapter 1 HTS Methods: Assay Design and Optimisation; 1.1 Introduction; 1.2 HTS at AstraZeneca; 1.2.1 Criteria and Acceptance; 1.2.2 Robustness/Reliability; 1.2.3 Analysing Data to Define Robustness/Reliability; 1.2.4 As Simple to Run as Possible; 1.2.5 Assay Validation; 1.3 Summary; References; Chapter 2 Considerations Related to Small-molecule Screening Collections; 2.1 Introduction; 2.2 General Considerations Related to HTS Compound Collections; 2.2.1 Determination of Screening Objectives

2.2.2 Size of HTS Compound Collections2.2.3 Chemical Diversity in Compound Collections; 2.2.4 Quality of Compounds in Screening Collections; 2.3 Sources of Compounds in Screening Collections; 2.3.1 Natural Products in Screening Collections; 2.3.2 Synthetic Drug-like Compounds; 2.3.3 Diverse Collections; 2.4 Performance of Compounds in Screening Collections; 2.4.1 Background; 2.4.2 Performance of Compounds from Different Sources; 2.4.3 Performance Diversity of Compound Collections; 2.4.4 Pan Assay Interference Compounds; 2.4.5 Dark Chemical Matter; 2.5 Conclusions and Discussion; References

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