Humanized mice

by Habu, Sonoko Nomura, Tatsuji Watanabe, Takeshi

Type Book

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In a humanized mouse transplanted human tissues and cells show the same biological function as they do in the human body. It has become possible to study the pathophysiology and treatment of human diseases in mice with excellent reproducibility, a remarkable breakthrough. Unsurprisingly, the humanized mouse is proving to be one of the most powerful tools in basic and clinical research. This fascinating and authoritative review considers mouse models that display the characteristics of a range …

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Title Statements

Full title :Humanized mice / Tatsuji Nomura, Takeshi Watanabe, Sonoko Habu, editors.

Summary

In a humanized mouse transplanted human tissues and cells show the same biological function as they do in the human body. It has become possible to study the pathophysiology and treatment of human diseases in mice with excellent reproducibility, a remarkable breakthrough. Unsurprisingly, the humanized mouse is proving to be one of the most powerful tools in basic and clinical research.

This fascinating and authoritative review considers mouse models that display the characteristics of a range of human cell and tissue types but focuses on mice with the human immune system. It also considers the future prospects for developing and using humanized mice in a new era for research in human disease.

Edition Statements

Publication Date:2008.

Publication Statements

Publisher(s):Springer
Place of Publication:Berlin
Language:eng
Publication Date:2008.

The Physical Object

Description:xiii, 199 pages : : illustrations.

Edition Identifiers

ISBN:9783540756460, 3540756469, 9783540756477, 3540756477
oclc:ocn226973304
LC Classification:QR1
Dewey Decimal:599.3530724

Basic concept of development and practical application of animal models for human diseases / T. Nomura [and others] -- Humanized SCID mouse models for biomedical research / T. Pearson, D.L. Greiner, and L.D. Shultz -- NOD/Shi-scid IL2r[gamma][null] / M. Ito, K. Kobayashi, and T. Nakahata -- Humanizing bone marrow in immune-deficient mice / K. Ando, Y. Muguruma, and T. Yahata -- The differentiative and regenerative properties of human hematopoietic stem-progenitor cells in NOD-SCI/IL2r[gamma][null] mice / F. Ishikawa [and others] -- Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system / R. Ito [and others] -- Humanized immune system (HIM) mice as a tool to study NK cell development / N.D. Huntington and J.P. Di Santo -- Human T cell development and HIV infection in human hemato-lymphoid system mice / S. Baenziger [and others] -- Humanized mice for human retrovirus infection / Y. Koyanagi, Y. Tanaka, M. Ito, and N. Yamamoto -- Functional and phenotypic characterization of the humanized BLT mouse model / A.K. Wege [and others] -- Novel metastasis models of human cancer in NOG mice / N. Nakamura and H. Suemizu -- In vivo imaging …

Subjects

Fulltext Humanized mice Internet resources Mice as laboratory animals Mice, Transgenic Models, Animal Möss som försöksdjur Souris (Animal de laboratoire) Souris transgéniques Transgenic mice