Imaging the aging brain

"The importance of brain imaging for clinical diagnosis and the understanding of basic mechanisms of disease and aging is well-known in medical science. These techniques have been the basis for numerous studies that have striven to better detect neurological disorders and age-related change in the brain." "This book - co-edited by world-renowned Alzheimer's disease researcher and clinician, William Jagust, and world-renowned neurologist and cognitive neuroscientist, Mark D'Esposito - contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain. Topics covered include technical factors in brain imaging, pathological basis of age-related structural and functional changes, neurochemistry and genetics of brain imaging in aging, and the use of imaging techniques in diagnosis, longitudinal testing, drug development and testing, and presymptomatic detection. The book is intended to be both a detailed review of the current status of brain imaging and aging and to serve as an introduction to the field for those who may be starting investigations using imaging techniques of PET, structural MRI, and functional MRI. It covers basic science approaches such as using fMRI to probe networks, as well as recent developments such as amyloid imaging and the use of imaging as a biomarker in clinical trials." "The field of brain aging is undergoing rapid expansion because of new techniques such as fMRI and amyloid imaging which have been applied to both basic and clinical problems. Imaging the Aging Brain is a compendium of relevant knowledge and up-to-date analysis. Written by leaders in neurological research and presented in color, this book is as timely as it is thorough."--Jacket.

Introduction: still more questions than answers / William Jagust and Mark D'Esposito -- Methodological and conceptual issues in the study of the aging brain / Mark D'Esposito, William Jagust, and Adam H. Gazzaley -- Neuropathology of aging / Dara L. Dickstein, John H. Morrison, and Patrick R. Hof -- A systems approach to the aging brain : neuroanatomic changes, their modifiers, and cognitive correlates / Naftali Raz and Kristen M. Kennedy -- Dopaminergic modulation of cognition in human aging / Shu-Chen Li [and others] -- Cognitive reserve and aging / Yaakov Stern -- Compensatory reorganization of brain networks in older adults / Cheryl L. Grady -- Cross-species imaging applied to the aging brain : dissociating Alzheimer's disease from normal aging / Sidonie T. Jones and Scott A. Small -- Genetics and imaging in Alzheimer's disease / Susan Y. Bookheimer -- Imaging cognitive decline in aging : predicting decline with structural imaging / Jeffrey Kaye -- The early detection of Alzheimer's disease with positron emission tomography / Rachel Mistur [and others] -- Structural imaging of mild cognitive impairment / Clifford R. Jack, Jr. -- Functional imaging with FDG-PET in mild cognitiv…