Immunopsychiatry: an introduction

by Bullmore, Edward T. Dantzer, Robert Harrison, Neil, (Neil Andrew) Khandaker, Golam M.

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Title Statements

Full title :Immunopsychiatry : an introduction / edited by Neil Harrison, Golam Khandaker, Edward Bullmore, Robert Dantzer.

Summary

"Once thought to be an immune-privileged site, we now know that there is a complex and essential bidirectional interplay between the central nervous system (CNS) and the immune system. Technological advances in imaging, genomic medicine and immunology have resulted in major revisions to some of the most fundamental and long-held assumptions in neuroscience, and we now understand that the immune system is critically involved not only in brain pathology, but also in the normal processes of brain development and homeostasis. 'Immunopsychiatry', namely the study of the interactions between neuroscience, mental health and the immune system, has rapidly become a major priority for psychiatric research. Accumulating evidence indicates roles for the immune system in the pathophysiology of many neurodegenerative and psychiatric disorders including Alzheimer's disease (AD), schizophrenia, major depressive disorder (MDD), multiple sclerosis (MS) and others. In particular, pro-inflammatory cytokines associated with inflammation, which is common to many of these disorders, can influence the brain to bring about a host of physiological as well as behavioural alterations such as changes in mood and cognition. Raised pro-inflammatory cytokines are consistently reported in MDD and schizophrenia. Moreover, systemic inflammation brought about by acute infection, diabetes, obesity and atherosclerosis can accelerate cognitive decline in the elderly and present significant risk for the development or acceleration of AD and delirium. With this new knowledge come new targets to be exploited as biomarkers for diagnosis or informing treatment. A number of immunemodulating therapeutics are currently being trialled for the treatment of MDD, schizophrenia, AD and others"--

Edition Statements

Publication Date:©2021

Publication Statements

Publisher(s):Cambridge University Press
Place of Publication:Cambridge, United Kingdom
Language:eng
Publication Date:©2021

The Physical Object

Description:1 online resource (x, 346 pages, 12 unnumbered pages of plates) : : illustrations (some color)

Edition Identifiers

ISBN:9781108539623, 1108539629
oclc:on1257314959
LC Classification:RC454
Dewey Decimal:616.89/079

Basic concepts in immunobiology / Lorinda Turner and Neil Harrison -- The evolution of immunological research in psychiatric disorders / Prof Keith Kelley -- Stress, immune system and the brain / Julie-Myrtille Bourgognon, Alison McColl, Maria Suessmilch, Rajeev Krishnadas and Jonathan Cavanagh -- Role of infection and inflammatory cytokines / Prof Alan Brown, Fiona Conway, Genvieive Falabella and Carly Apar -- Role of auto-immunity, anti-NMDA receptor and related antibodies / Mike Zandi and Esha Abrol -- Effectiveness of Immunotherapies for Psychotic Disorders / Rachel Upthegrove and Bill Deakin -- Inflammation, sickness behaviour and depression / Neil Harrison, Alessandro Colasanti and Golam Khandaker -- Inflammation, antidepressant response and immunotherapies for depression / Golam Khandaker, Prof Ed Bullmore and Nils Kappelmann -- Role of Microglia in Neurodegenerative Disease / Colm Cunningham and Donal Skelly -- Role of inflammation in Parkinson's disease dementia and dementia with Lewy body / John O'Brien and Ajenthan Surendranathan -- The role of adaptive and innate immunity in Alzheimer's disease / Clive Holmes -- The immune system and anxiety disorders / Vasaliki Michop…

Subjects

Immune System -- immunology Immunothérapie Immunotherapy Immunotherapy -- methods Maladies mentales -- Immunologie MEDICAL -- Mental Health Mental Disorders -- immunology Mental illness -- Immunological aspects