Intermediate filament proteins

by Liem, Ronald Kian Hong Omary, M. Bishr

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Title Statements

Full title :Intermediate filament proteins / edited by M. Bishr Omary and Ronald K.H. Liem.

Edition Statements

Publication Date:2016.

Publication Statements

Publisher(s):Academic Press, an imprint of Elsevier
Place of Publication:Waltham, MA
Language:eng
Publication Date:2016.

Notes

Internet - monographie

ScienceDirect

VERSEMENT EN LOT.

The Physical Object

Description:1 ressource en ligne.

Edition Identifiers

ISBN:9780128034910, 0128034912
oclc:ocn987768530
LC Classification:QD431
Dewey Decimal:572/.67

Front Cover; Intermediate Filament Proteins; Copyright; Dedication; Contents; Contributors; Preface; References; Acknowledgments; Part I: General Methods to Study IF Proteins; Chapter One: How to Study Intermediate Filaments in Atomic Detail; 1. Introductory Remarks; 2. Bioinformatics; 3. X-ray Crystallography; 3.1. Design of IF Protein Fragments for Crystallization; 3.2. Protein Expression; 3.3. Purification; 3.4. Crystallization; 3.5. X-ray Data Collection; 3.6. Phasing by Molecular Replacement; 3.7. Experimental Phasing Using Heavy Atoms; 3.8. Structure Refinement and Validation

3.9. Limitations and Pitfalls3.10. Obtained Structures and Impact; 4. Electron Paramagnetic Resonance with Site-Directed Spin Labeling; 4.1. Principle; 4.2. Sample Preparation and Measurements; 4.3. Data Interpretation and Impact; 4.4. Limitations and Outlook; 5. Concluding Remarks; Acknowledgments; References; Chapter Two: Mechanical Properties of Intermediate Filament Proteins; 1. Introduction; 2. Viscoelasticity of Purified IFs In Vitro; 3. IFs and the Mechanical Properties of Cells; 3.1. Type III IF: Vimentin and Desmin; 3.1.1. Knockout Models of Vimentin

3.1.2. Drugs and Proteins Disrupting Vimen…