Mendelian randomization: methods for using genetic variants in causal estimation

by Burgess, Stephen

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Title Statements

Full title :Mendelian randomization : methods for using genetic variants in causal estimation / Stephen Burgess, Simon G. Thompson.

Edition Statements

Publication Date:©2015

Publication Statements

Publisher(s):Chapman & Hall/CRC
Place of Publication:Boca Raton, FL
Language:eng
Publication Date:©2015

The Physical Object

Description:1 online resource (xiv, 210 pages) : : illustrations

Edition Identifiers

ISBN:9781466573185, 146657318X
oclc:ocn903245878
LC Classification:RB155
Dewey Decimal:616.042015195

Introduction and motivation -- What is Mendelian randomization? -- Assumptions for causal inference -- Methods for instrumental variable analysis -- Examples of Mendelian randomization analysis -- Generalizability of estimates from Mendelian randomization -- Weak instruments and finite-sample bias -- Multiple instruments and power -- Multiple studies and evidence synthesis -- Example : the CRP CHD genetics collaboration -- Future directions.

Subjects

genetic variation Génétique médicale -- Méthodes statisti… HEALTH & FITNESS -- Diseases Human genetics -- Variation MEDICAL -- Clinical Medicine MEDICAL -- Diseases MEDICAL -- Evidence-Based Medicine MEDICAL -- Internal Medicine Medical genetics -- Statistical methods Mendelian Randomization Analysis -- met… Statistics as Topic -- methods Variabilité génétique