Mitochondrial dysfunction caused by drug and environmental toxicants

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods• Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects• Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development• Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Front Matter -- Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity / Gavin P McStay -- The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity / Kathleen M Giacomini, Huan-Chieh Chien -- Structure-Activity Modeling of Mitochondrial Dysfunction / Steve Enoch, Claire Mellor, Mark Nelms -- Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity / Haider Raza, F Peter Guengerich, Narayan G Avadhani -- Mitochondrial Dysfunction in Drug-Induced Liver Injury / Annie Borgne-Sanchez, Bernard Fromenty -- Evaluating Mitotoxicity as Either a Single or Multi-Mechanistic Insult in the Context of Hepatotoxicity / Amy L Ball, Laleh Kamalian, Carol E Jolly, Amy E Chadwick -- Cardiotoxicity of Drugs / Zoltan V Varga, Pal Pacher -- Skeletal Muscle Mitochondrial Toxicity / Eric K Herbert, Saul R Herbert, Karl E Herbert -- Manifestations of Drug Toxicity on Mitochondria in the Nervous System / Jochen H M Prehn, Irene Llorente-Folch -- Nephrotoxicity / Ana Belén Sanz, Maria Dolores Sanchez-Niño, Adrian M Ramos, Albe…