Molecular immunotoxicology

The first comprehensive reference on immunotoxicology using analyses based on molecular effects rather than on animal models. Following an introduction to immune system pathways and toxicity mechanisms from a systemic perspective, the main part of the book surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic e.

Molecular Immunotoxicology; Contents; Preface; List of Contributors; Chapter 1 The Evolution of Immunotoxicology; 1.1 Introduction; 1.2 Immune-Mediated Environmental Lung Diseases; 1.3 Immunotoxic Drug Reactions; 1.4 Autoimmunity; 1.5 Immunosuppression; 1.6 Allergic Contact Dermatitis (ACD); 1.7 Summary; References; Chapter 2 Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity; 2.1 Introduction; 2.2 Mechanisms of Immunotoxicity; 2.2.1 Interference with Cellular Signaling; 2.2.1.1 Receptor-Mediated Immunotoxicity; 2.2.1.2 Non-receptor-Mediated Immunotoxicity.

2.2.2 Adducts Formation and Role of ROS2.3 Conclusions; References; Chapter 3 Use of Toxicogenomics in Immunotoxicology; 3.1 Introduction; 3.2 Toxicogenomics; 3.2.1 Profiling Gene Expression; 3.2.2 Pathway Arrays; 3.2.3 Comparative Evaluation of Immunotoxicants; 3.2.4 miRNA and siRNA, Gene Expression Regulators; 3.2.5 mRNA Splicing; 3.2.6 RNA-Seq; 3.2.7 Proteomics; 3.2.8 Molecular Genomics; 3.2.9 Phenotypic Anchoring, Dose Response, Time Course; 3.3 Bioinformatics and Data Analysis; 3.3.1 Effect Markers and Machine Learning.

3.4 Multiple Omic Approaches in the Evaluation of Immunosuppressive Compounds3.4.1 …