Multiple Sclerosis and CNS Inflammatory Disorders

Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides the scientific basis of multiple sclerosis including etiology, epidemiology, and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying treatment algorithms for relapsing-remitting multiple sclerosis, switching therapy, and progressive multiple sclerosis treatment algorithm.

Clinical concerns.

Multiple Sclerosis and CNS Inflammatory Disorders; Copyright; Contents; Contributors ; Series Foreword ; Preface; 1 Etiology ; Background; Genes; Gender effects: Genetic or biologic?; The role of the environment; Environmental MS risk factors: The major players; Vitamin D; Infection; Smoking; Combining risk factors; Conclusion; Acknowledgment; References; 2 Immunopathogenesis of Multiple Sclerosis ; What does the neuropathology of MS tell us about its pathogenesis?; Gray matter pathology; Multiple sclerosis as an autoimmune disease; Candidates for the self-antigen in multiple sclerosis.

Antigen spreadingEpitope spreading; Outside-in versus inside-out?; Lymphocyte trafficking into the CNS ; Role of T cells in MS ; Role of B cells and humoral immunity; Role of microglia and macrophages; Role of other cells: Dendritic cells and astrocytes; Role of cytokines; What might trigger autoimmunity?; Further Reading; 3 Diagnostic Process ; Introduction; Clinical features of MS ; Defining MS; MS disease courses; Common symptoms in MS ; Diagnostic evaluation of MS ; MRI; Revised McDonald criteria for diagnosis of MS ; Ancillary testing in the diagnosis of MS.

Differential diagnosis of MS Conc…