Neuronal and synaptic dysfunction in autism spectrum disorder and intellectual disability

The first edition of this text describes the function of the major genes associated to ASD and ID, and discusses the crucial role that neuronal development and synaptic activity play in proper brain function. This volume collects some of the major studies in the field of autism, highlighting genetic, molecular, and clinical aspects. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional neuronal and synaptic anomalies, and potentially ameliorate some ASD and ID symptoms. thus this book represents a strong reference and serves as a resource for scientists and clinicians in all biomedical science specialties.

List of contributors -- Preface -- Acknowledgments. I Autism spectrum disorders and intellectual disability: genetic and non-genetic causes : Experimental tools for the identification of specific genes in autism spectrum disorders and intellectual disability / Yiping Shen and Xiaohong Gong -- Genetic causes of autism spectrum disorders / Guillaume Huguet and Thomas Bourgeron -- Genetics of X-linked intellectual disability / Charles E. Schwartz and Luigi Boccuto -- Genetic causes of intellectual disability: the genes controlling cortical development / Yoann Saillour and Jamel Chelly -- Immune dysfunction in autism spectrum disorder / Natalia V. Malkova and Elaine Y. Hsiao. 2 Function of mutated genes in intellectual disability (ID) and autism : Synapse proteomes and disease: the MASC paradigm / Alex Bayés and Seth G.N. Grant -- The function of MeCP2 and its causality in Rett Syndrome / Janine M. Lamonica and Zhaolan Zhou -- FMRP and the pathophysiology of fragile X syndrome / Stephanie A. Barnes, Sophie R. Thomson, Peter C. Kind, and Emily K. Osterweil -- X-linked ASDs and ID gene mutations / Edoardo Moretto, Maria Passafaro, and Silvia Bassani -- SHANK mutations in intellectual di…