Nitric oxide and infection

Familiarity with nitric oxide is essential to a modern understanding of pathophysiologic mechanisms of infectious disease. Recent research has established nitric oxide and related reactive nitrogen intermediates to be important molecular mediators of diverse physiologic processes such as control of vascular tone, regulation of the immune system, and microbial and tumor cell growth. This book contains chapters by the leading researchers in the field and examines the biology and biochemistry of nitric oxide and its role in a variety of specific infections ranging from sepsis, tuberculosis and malaria to viral myocarditis, influenza, and AIDS.

Pt. A. Introduction. 1. An Overview of Nitric Oxide in Infection / Ferric C. Fang -- Pt. B. Historical Aspects of Nitric Oxide. 2. The Discovery of the Biological Synthesis of Nitric Oxide / John B. Hibbs, Jr. and Neil R. Bastian -- Pt. C. Biological Roles of Nitric Oxide. 3. Biochemistry of Nitric Oxide / Benjamin Gaston and Jonathan S. Stamler. 4. Enzymology of Nitric Oxide Biosynthesis / Benjamin Hemmens and Bernd Mayer. 5. Cytokine Regulation of Nitric Oxide Production / Heiko Muhl and Charles A. Dinarello. 6. Human Mononuclear Phagocyte Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression / J. Brice Weinberg. 7. Cardiovascular Actions of Nitric Oxide / Daryl D. Rees. 8. Biochemical Regulation of Nitric Oxide Cytotoxicity / Andrew J. Gow, Raymond Foust III and Stuart Malcolm / [et al.]. 9. Cytoprotective Effects of NO against Oxidative Injury / David A. Wink, Yoram Vodovotz and William DeGraff / [et al.]. 10. Immunomodulatory Actions of Nitric Oxide / Iain B. McInnes and Foo Y. Liew. 11. Nitric Oxide and Epithelial Host Defense / Nigel Benjamin and Roelf Dykhuizen. 12. Antimicrobial Properties of Nitric Oxide / Mary Ann DeGroote and Ferric C. Fang -- Pt. D. N…