NMR Spectroscopy: Basic Principles, Concepts and Applications in Chemistry

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and widely used techniques in chemical research for investigating structures and dynamics of molecules. Advanced methods can even be utilized for structure determinations of biopolymers, for example proteins or nucleic acids. NMR is also used in medicine for magnetic resonance imaging (MRI). The method is based on spectral lines of different atomic nuclei that are excited when a strong magnetic field and a radiofrequency transmitter are applied. The method is very sensitive to the features of molecular structure because also the neighboring atoms influence the signals from individual nuclei and this is important for determining the 3D-structure of molecules. This new edition of the popular classic has a clear style and a highly practical, mostly non-mathematical approach. Many examples are taken from organic and organometallic chemistry, making this book an invaluable guide to undergraduate and graduate students of organic chemistry, biochemistry, spectroscopy or physical chemistry, and to researchers using this well-established and extremely important technique. Problems and solutions are included.

NMR Spectroscopy -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 Introduction -- 1.1 Literature -- 1.2 Units and Constants -- References -- Part I Basic Principles and Applications -- Chapter 2 The Physical Basis of the Nuclear Magnetic Resonance Experiment. Part I -- 2.1 The Quantum Mechanical Model for the Isolated Proton -- 2.2 Classical Description of the NMR Experiment -- 2.3 Experimental Verification of Quantized Angular Momentum and of the Resonance Equation

2.4 The NMR Experiment on Compact Matter and the Principle of the NMR Spectrometer -- 2.4.1 How to Measure an NMR Spectrum -- 2.5 Magnetic Properties of Nuclei beyond the Proton -- References -- Chapter 3 The Proton Magnetic Resonance Spectra of Organic Molecules -- Chemical Shift and Spin-Spin Coupling -- 3.1 The Chemical Shift -- 3.1.1 Chemical Shift Measurements -- 3.1.2 Integration of the Spectrum -- 3.1.3 Structural Dependence of the Resonance Frequency -- A General Survey -- 3.2 Spin-Spin Coupling

Chapter 4 General Experimental Aspects of Nuclear Magnetic Resonance Spectroscopy -- 4.1 Sample Preparation and Sample Tubes -- 4.2 Internal and External Standards -- Solvent Effects -- 4.3 Tuning the Sp…