Optogenetics
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optog…
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- Full title :Optogenetics
Summary
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and.
Read More ↓Edition Statements
- Publication Date:2013.
Publication Statements
- Publisher(s):De Gruyter
- Language:eng
- Publication Date:2013.
The Physical Object
- Description:1 online resource
Edition Identifiers
- ISBN:9783110270716, 3110270714, 9783110270723, 3110270722
- oclc:on1229633226
- LC Classification:QP364.5,D384 2013
- Dewey Decimal:591.188
Table of Contents
List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools.
2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem.
4.3 The large scale challenge of circuit neurosciences4.4 The curren…
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